A psychodynamic approach to understanding creativity was proposed by Sigmund Freud, who suggested that creativity arises as a result of frustrated desires for fame, fortune, and love, with the energy that was previously tied up in frustration and emotional tension in the neurosis being sublimated into creative activity. 

The study found that creative innovation requires “coactivation and communication between regions of the brain that ordinarily are not strongly connected“. Highly creative people who excel at creative innovation tend to differ from others in three ways: they have a high level of specialized knowledge, they are capable of divergent thinking mediated by the frontal lobe, and they are able to modulate neurotransmitters such as norepinephrine in their frontal lobe. Thus, the frontal lobe appears to be the part of the cortex that is most important for creativity. The study also explored the links between creativity and sleep, mood and addiction disorders.
A different study found that creativity is greater in schizotypal (exhibiting, or being patterns of thought, perception, communication, and behavior suggestive of schizophrenia but not of sufficient severity to warrant a diagnosis of schizophrenia <schizotypal personality>)individuals than either normal or fully schizophrenic individuals. While divergent thinking was associated with bilateral activation of the prefrontal cortex, schizotypal individuals were found to have much greater activation of their right prefrontal cortex. these individuals are better at accessing both hemispheres, allowing them to make novel associations at a faster rate. Ambidexterity(unusually skillful; facile: master of all trades, familiar with all media) is also associated with schizotypal individuals. 

For more reference :
http://en.wikipedia.org/wiki/Creativity